Unlike cisplatin, organorhenium compounds are relatively nontoxic to normal cells. Many organorhenium compounds are highly cytotoxic on cancer cells. We have synthesized a series of organorhenium ibuprofenato, picolinato and nicotinato complexes from the reactions of the corresponding pentylcarbonato complexes with ibuprofen, picolinic acid and nicotinic acid respectively. A few of these complexes have been characterized through X-ray crystallography. Many of these complexes have very low IC-50 values on breast cancer cells. For example, the IC-50 value of the ibuprofanato complex, IB-6, is 0.958 ± 0.261 µM on MCF-7 breast cancer cells. Likewise, the IC-50 value of the nicotinato complex, NIC-7 is 0.591 ± 0.145 µM on MDA-MB-231 cells. We will present the synthesis, characterizations, stability, DNA-binding and cytotoxic activity of these complexes.

Organorhenium ibuprofenato, picolinato and nicotinato complexes as anticancer agents

255th National Meeting (2018)

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