Amphiphilic diblock copolymers have been widely studied for biomedical applications, while amphiphilic homopolymers are relatively under investigation. In this project, we synthesized two novel amphiphilic homopolymers and explored their thermo-responsive and self-assembly properties. Two novel oligo(ethylene glycol) functionalized delta valerolactone monomers were synthesized and were polymerized to generate homopolymers. These polymers exhibit amphiphilic properties and self-assemble to form micelles in water. The synthesized polymers are also thermo-responsive with LCSTs of ~31 degree Celsius and ~40 degree Celsius respectively. These amphiphilic homopolymers are biocompatible and biodegradable and will be further investigated for drug delivery applications.<br/>

Synthesis, self-assembly, and temperature-responsiveness of novel functional poly(valerolactone)s

255th National Meeting (2018)

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