255th National Meeting (2018)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

American Chemical Society

Current Topics

Nano structure design for RNA interference

Investigating the roles of Mycobacterium smegmatis L,D-transpeptidases in cell wall biosynthesis

Synthesis and application of small molecule probes for lipid labeling

Demonstration of horizontal gene transfer from genetically engineered cyanobacteria to wild-type E. coli

Human glutathione synthetase: Negative cooperativity and substrate binding studies

LC-MS/MS-based analytical method for Marfey’s reagent derivatized amino acid stereoisomers and it’s application to biological samples

Heterologous expression of Fe+3/phytosiderophore (PS) transporter isolated from the roots of Fe+-starved from oats (Avena sativa)

6-Thiopurine: Targeting UDP-glucose dehydrogenase and its efficacy effects

Effect of the antimicrobial peptide combi-2 on lipid bilayers mimicking bacterial membranes

Trehalose monomycolate analogue containing a cleavable biotin affinity tag for labeling and identifying o-mycoloylated proteins in Corynebacterineae

Analysis of eyes shut (EYS) function during intestinal regeneration in Drosophila melanogaster

Elucidating the regulatory phosphorylation hotspots of full-length BRAF through enzymological analyses

Mechanism of a class C radical SAM thiazole methyltransferase

Identification of ssDNA aptamer specific to an herbicide

Careful what you label for: A Story of peril and intrigue in fluorophore labeling for tracking cellular uptake

DNA:RNA hetero-guanine quadruplex formation: Duplex guidance and disruption by peptide nucleic acid

Modular biotinylated and photoactive NAADP analogs

RNA-seq analysis of Komagataeibacter xylinus E25 A:kan and AB::kan mutants

Characterization of a small molecule’s influence on a Ras-related protein-protein interaction

Large increases in photostability and upconverted energy transfer in lanthanide nanocrystal-based biosensors

Peptidomimetic inhibitors of the KDM4-subfamily of histone lysine demethylases: Transitioning from substrate to inhibitor

Liposomal delivery of diacylglycerol lipase-beta inhibitors to macrophages dramatically enhances selectivity and efficacy in vivo

Selective peptide binders for PDL1 as an immunogenic target in cancer

Mechanistic insights into quorum sensing regulator protein-DNA binding

PIP-on-a-chip assay: A microfluidics based approach to study viral protein – membrane interactions

Toward development of protein-polymer conjugates for biocatalytic cyclopropanation

Interactions of platinum(II) small molecules with RNA and implications of platination on RNA depurination and cell cytotoxicity

Effect of substrate presentation and Michaelis complex stability on neuraminidase 2 (NEU2) specificity

Unexpected binding specificity of 2OST: Implications for heparan sulfate biosynthesis

"Geometric mutation" for decoupling receptor signaling crosstalk at phagosome membranes

Development of a chemical proteomic strategy to target diacylglycerol kinases

Investigating plasmid DNA maintenance in transformed E. coli

Polyacrylamide nanoparticles: A conjugatable platform for use in the diagnosis and treatment of cancer

Regulatory mechanism of nitric oxide synthase by cav-1 and calmodulin

Characterization of the 3rd and 4th EF-hand motifs of NADPH oxidase 5 by calorimetry

Interaction of aurein 1.2 with vesicles mimicking normal and cancer cell membranes

Fullmetal alchemy: Using kinetic isotope effects to interrogate divalent metal ion catalysis in phosphoryl transfer enzymes

Biochemistry of clinically relevant ITPase mutants

QM-cluster model examination of a biphenyl transition state “trapped” within an engineered Thr-tRNA synthetase

Investigating novel RNA and nucleotide metabolic pathways in bacterial physiology

Novel phosphinate-based near-infrared fluorophores and their biological application

Chemical approaches to investigate gene regulation by histone sumoylation

Induction of cell death mechanisms with light by a novel porphyrin derivative

Design and characterization of a dual-loop G-quadruplex for molecular logic gates

Short dietary peptide IRW elicits its pharmacological effects via PGC1α axis

Chemical reactive anchoring lipids with different performance for cell surface re-engineering

New views of head-to-middle prenyltransferases

The small molecule 2-Azido-2-deoxy-glucose is a metabolic chemical reporter of O-GlcNAc modifications in mammalian cells, revealing an unexpected promiscuity of O-GlcNAc transferase

Force-selected molecular printing with high precision and versatility

Increasing solubility of the serine protease dipeptidyl peptidase-4 via protein truncation

Structure and mechanism of isopropylmalate dehydrogenase from Arabdiopsis thaliana: Insights on leucine and aliphatic glucosinolate biosynthesis

Mutational analysis of A2-domain interface residues in promoting the structural stability of blood coagulation factor vIIIa: A computational binding free-energy analysis study

Optimization of previously developed RNA-TAG system for covalent modifaction of hairpin RNA-hairpin

Optimizing methods for analyzing O-GlcNAc modifications

Expanding the scope of RNA-TAG: From cell imaging to the conjugation of modified mRNA

FRET based assays to study the binding of fibroblast growth factor to its receptor

Lipid membrane formation in artificial cells

Analyzing the role of G●U base pairs on the melting behavior of the S. enterica htrA RNA thermometer

Direct detection of xanthurenate radical from enzymatic oxidation of xanthurenic acid

A beacon in the night: Chemiluminescence imaging agents for whole animal imaging

The pattern of occurrence of cytosine in the genetic code

Synthesis, characterization and biological studies of cobalt(II) Schiff bases derived from o-vanillin with series of aromatic amines

Revisiting the acetaminophen free radical

Toward deciphering the biochemistry of DNA thymidine hypermodification in bacteriophages

Expression and characterization of dehydrogenase domain of NADPH oxidase 5

Role of free-living nematodes in nutrient cycling in arid grasslands

High throughput in vivo screening assay for novel inhibitors of extracellular heme sensing and utilization in Pseudomonas aeruginosa

Using dye molecules to study xenobiotic transport in the mosquito, A. aegypti

The preliminary study of hOLA1 N-terminal methylation catalyzed by NRMT1

Characterization of the binding partners of MitoNEET

Evaluation and biophysical characterization of novel antimicrobial peptides: "A water purification approach"

Human skin RNases offer dual protection against invading bacteria

Allosteric activation by membranes regulates substrate specificity of lipolytic enzymes

Arylboronic acid-catalyzed hydrolysis of salicylaldehyde imines mimics Michaelis-Menten enzyme-substrate kinetics

Design, synthesis, molecular docking and antimicrobial activity of New 7-(4-(2-((1,2,4-triazol-3-yl)thio)acetyl)piperazin-1-yl) derivatives of ciprofloxacin

Synthesis, spectroscopic investigation, biological screening, interaction with SS-DNA and DFT study of ferrocene-modified ureas

Cannabidiol dimethyl ether synthesis pathways

Toward the detection of cancers by chemotaxis of C. elegans

Automated and high-resolution force spectroscopy for biochemical applications

Design of a halophilic peptide based on halophilic protein motifs

Isolation and characterization of a novel intermediate of thymidylate synthase: Possibility of a new class of chemotherapeutic drugs targeting thymidylate synthase

Functional analysis of O-GlcNAc modified α-synuclein using synthetic protein chemistry

Controlled microbial biosynthesis of Cd and Zn quantum dots

Conserved aromatic residues at the dimer-dimer interface in the yeast peroxiredoxin Tsa1 facilitate decamer formation and biological function

Inhibition of amyloid fibril formation via naturally occuring phenolic compounds monitored by atomic force microscopy

Isolation and characterization of antibacterial molecules from various fruits and spices

Coiled-coil peptides: A template for investigating connection between stability and sequences

Elucidating the role of the sRNA C.0293 in the bacterial stress response

Stable binding of protein RsmG to 16S helix 18 requires RNA-protein and RNA-RNA contacts formed by the 16S 5'-domain RNA

Identification of vaginal bacterial species that are mutually and differentially antagonistic with strains of Candida albicans

Y-FAST as a fluorescent color switchable reporter in living cells

Structure-activity relationships for activation of Arabidopsis thaliana cytokinin receptors by analogs of N6-benzyladenine

Direct ESR detection of lignin monomer radicals

A possible mechanism of turmeric anti-cancer activity

Effects of familial mutations on the structure and assembly of a peptide derived from Aβ16–36

Understanding the mechanism of mutation suppression by a conserved oxidant defense protein in yeast

Human serum albumin is conformationally changed in the presence of epigallocatechin gallate using FRET (Förster resonance energy transfer)

Conformational preferences in beta-sheet peptidomimetics

Trehalose monomycolate mimic chemical reporter: A strategy for detecting, profiling and identifying O-mycoloylated proteins in mycobacterium

Prolyl oligopeptidase family protein 2 (POP2): A protease with a taste for antibodies

Current Topics

No video is available

Nano structure design for RNA interference