255th National Meeting (2018)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

American Chemical Society

Current Topics

Development of a chemical proteomic strategy to target diacylglycerol kinases

NADPH-dependent reductive aminases

pH-dependent studies of the reductive half-reaction of methylenetetrahydrofolate reductase from Escherichia coli

Role of CDKs on glioblastoma cell growth

Aromatic ynamines: A new bio-orthogonal reactive group for step-efficient, sequential bioconjugation

Thiophene-N-methylbenzimidazole σ–hole module as a new road to specific recognition of mixed DNA sequences

New photoaffinity labeling module

Tissue-specific loss of SMN and its effect on the immune response of Drosophila melanogaster

Correlating bacterial diversity to nitrogen contamination of alluvial aquifers in Iowa

Prevention and treatment of oral gonorrhea using antimicrobial GUMBOS

Nanosized calcium-responsive contrast agents for functional MRI applications

Cloning and expression of recombinant chondroitinase AC II and its comparison to the Arthrobacter auescens enzyme

First structure of a designed minor groove binding heterocyclic cation that specifically recognizes mixed DNA base pair sequences

Protein determinants of anion binding: Application to sodium iodide symporter

Progress towards the structural determination of the telomere associating protein Modigliani

Design of a dimeric aptamer against B-cell receptor

Triacylglycerols play a protective role during apoptosis

Amyloid diversity in yeast is promoted by prion-specific chaperone functions

Expressions of phenylalanine hydroxylase and various mutants

Stability of nonproteinogenic amino acids under extraterrestrial conditions

Role of cell-surface hemin receptors in the rapid uptake and photodynamic inactivation of staphylococci by Ga(III)-protoporphyrin IX

Short cationic peptides induce pH-sensitive non-leaky membrane fusion to enable cytoplasmic delivery of cell-impermeable compounds

Patronage of chemical safety and security among chemistry professionals

Progression towards structural determination and the understanding of protein-protein interactions of terminin complex proteins

Targeted depalmitoylation of N-Ras for suppression of oncogenic signaling pathways

Synthesis and characterization of biogenic selenium nanoparticles with antimicrobial properties made by Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli and Pseudomonas aeruginosa

Amyloid aggregation of the C-terminal peptide of BAX: A pro-apoptotic human protein

Synthetic α-helix mimetics for recognition of HIV TAR-RNA

Refractive index matching mounting media for best-in-class sample preservation and image quality

Structural and solution studies of DNA-binding by SloR, A Mn-dependent regulatory protein from Streptococcus mutans

A synthetic isoprenoid lipoquinone, menaquinone-2, adopts a folded conformation in solution and at a model membrane interface

Assessing apoptosis inducing factor (AIF) as a candidate tumor promoter

Designing peptide inhibitors for annihilating amyloid deposits: Treating Alzheimer’s disease

Biosynthesis of the antimycobacterial lasso peptide, lariatin A, in Escherichia coli

Cannabinoids as anti-cancer agents: What's really going on?

Dynamics of a π-stacked substrate analog in a flavoenzyme active site using 2D IR spectroscopy

High resolution measurement of membrane protein endocytosis

Structural changes of chloroplast signal recognition particle proteins studied by single molecule FRET during vectorial protein targeting

Perturbing the BfrB:Bfd interaction of Pseudomonas aeruginosa by chemical and genetic intervention causes irreversible accumulation of iron in BfrB

Base composition and sequence characteristics of the 5’UTR of BACE1 mRNA

Molecular dynamics simulations of inhibition and disease mechanisms of metabolite fibrils

Design of new natural cysteine protease inhibitors (CPI) in complex with cruzipain from T. cruzi

Heterochiral DNA strand displacement circuits

Synthesis and evaluation of Nebraska Red derivatives for protein labeling studies

Distinct immune responses with covalently-linked TLR agonist combinations for a Q-Fever vaccine

Investigating the dienophile effect on the fluorogenic efficiency of cycloaddition reactions with tetrazines

Quantifying tetracycline resistance genes in swine waste anaerobic digester over a period of 100 days

Noncovalent exocyclic methylene intermediate in flavin-dependent thymidylate synthase: Fact or artifact?

Mechanistic studies of copper-activated drugs against Gram-positive bacteria

Investigating the conformational dynamics of GLP-1R: A class B G protein-coupled receptor

Creating dense DNA phases with protein-crosslinked plasmids

Synthesis of diphosphate ProTides for enhancement of cellular metabolism

Analysis of dopaminergic derivatives in sulfotransferase SULT1A3

Pin1-histone H1 interactions: Towards an understanding of substrate specific activity

Oxidative damage affected by packaging density in sperm protamine-DNA complexes

An NMR based metabolomics approach to understanding biochar’s effects on Escherichia coli

Cyanocarbazole derivatives as universal bases

Phosphorylation and regulation of the splicing factor SRSF1 by a symbiotic kinase-kinase SRPK1-CLK1 complex

Crustin and related putative antimicrobial peptides in the lobster, Homarus americanus: Identification using transcriptomics with top-down and bottom-up peptidomic strategies

Use of synthetic peptidomimetics for a critical evaluation of Aβ structure and functions

Self-assembly and photophysical characterization of synthetically functionalized luciferins for detecting host-guest interactions

Evaluation of mosquito (A. aegypti) organic anion transporters through microinjection of sulfuryl group dyes

Enzymatic synthesis of endocannabinoids

Net1A inhibitors: Looking for synergy

Connecting genes to molecules: Identifying novel small molecules in microbe-plant interactions

Applications of multidimensional time model for PDF applied to Fokker- Planck equation and multi-scale time analysis to the rate of transcription or translation controlled by riboswitches

Fluorescent nucleoside analogues with new properties and structure-photophysics relationships

Engineering a replicative DNA polymerase for accurate bypass of damaged DNA

Site-directed mutagenesis of rSERT in preparation for future crosslinking studies

Addition of backbone modified amino acids to mRNA display via an editing-deficient aminoacyl-tRNA synthetase

Synthesis and screening of a β amino acid bisintercalator library

DNA patterning methods for the study of a designed bacterial community

Mechanism of triazolium salts on breast cancer cells

Wireless handheld sensor for salivary cortisol detection

Construction of synthetic membranes by chemoselective lipidation of peptides

Testing the limits of NO detection with liposome encapsulated spin trap

Investigations into the development of new penetrating chaperones: Smuggling therapeutics across gram-negative bacteria and the blood-brain barrier

AdCasT: A single vector system for tunable control of genome-wide genetic perturbations

Unveiling molecular mechanisms of kinesin-5 function using multiscale computational techniques

Ultraviolet light induced self-quenching of protein fluorescence

Catalysis of transthioacylation in the active centers of dihydrolipoamide acyltransacetylase components of 2-oxo acid dehydrogenase complexes: A reassessment of mechanism

Mechanistic insights into oligomer and fibril formation of amyloid-beta peptide

Probing the effects of oligomerization and heme pocket residues on the signal transduction within globin coupled sensors

Dual targeted nanoparticles for mitochondrial delivery of a cisplatin prodrug for prostate cancer therapy

Flow cytometry based high-throughput screen capable of sorting biofuel producing E. coli cells

Augmenting vaccine immunogenicity through the use of natural human anti-Rha antibodies and monoclonal Fc domains

Catalyzed reporter deposition for fluorescent labeling of cells using oxidative enzymes

LAT1 membrane transporter selectivity for L and D amino acids

Design, synthesis and biological evaluation of novel NSAIDs with improved gastrointestinal safety profile

Role of serine to threonine substitution in NrdF protein of ribonucleotide reductase enzyme

Structure-activity relationships of phosphocholine esters for anticancer activity

Metal binding affinity of Halobacterium salinarum cysteinyl-tRNA synthetase

Real-time ticking of a biological clock, assembled in a test tube

Mechanistic study of a peptide diastereomer with anti-cancer activity

Cellular effects of ligand binding to the Oxysterol-binding protein family (OSBP/ORP4)

The effect of oxidative stress on mitochondrial electron transfer flavoprotein: Pinpointing sequences adducted by 4-hydroxy-2-nonenal

Effects of the pro-cys-pro tripeptide stretch on the structural and biochemical properties of chloroperoxidase

Effect of substrate presentation and Michaelis complex stability on neuraminidase 2 (NEU2) specificity

Unexpected binding specificity of 2OST: Implications for heparan sulfate biosynthesis

"Geometric mutation" for decoupling receptor signaling crosstalk at phagosome membranes

Current Topics

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Development of a chemical proteomic strategy to target diacylglycerol kinases