Design of Experiments (DoE) on automated high throughput experimentation (HTE) platform has been applied to the optimization of a methyl ester hydrolysis. In addition to the methyl ester functionality, the starting material contains an oxetane ring, which is labile to acidic conditions, and a nitrile group that, under basic conditions, undergoes a competitive partial hydrolysis to afford an amide impurity. This case study describes our efforts to optimize the hydrolysis of the methyl ester under basic conditions while minimizing the amount of amide impurity

Application of miniaturized design of experiments studies to the optimization of a methyl ester hydrolysis

256th National Meeting (2018)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.