We have developed divergent C-H functionalization of nitropyrazoles with terminal alkynes. By taking advantage of high reactivity of nitropyrazoles, the C-H alkynylation of nitropyrazoles was achieved. Alternatively, when excess alkynes were employed, homo-dimerization was facilitated to give 1,3-diynes, which were subsequently reacted with nitropyrazoles to afford the corresponding hydroarylation products in a single pot operation. Mechanistic studies to elucidate the dichotomy of the catalytic system will be discussed along with proposed mechanisms.

Divergent C-H functionalization of nitropyrazoles with terminal alkynes through alkynylation and hydroarylation

256th National Meeting (2018)

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