The discovery of “smarter” insecticides that are pest selective and environmentally benign is a high priority for the continued control of vector-borne diseases. To meet this challenge, our program is pursuing rational design of small molecule insecticides that operate via unique modes of action in Aedes, Anopheles and Culex species. First, we have discovered new chemical series that selectively disrupt novel targets - mosquito G protein-coupled receptors (GPCRs) - and are lethal to the insect. Second, we have re-designed whole organism screening platforms to take advantage of new imaging technologies and identify novel, non-lethal chemistries that disrupt flavivirus transmission by the mosquito. The pros and cons of the target-based and empirical screening strategies will be presented, and prospects for the development of new and safer insecticide classes will be presented

Designing “smarter” insecticides for vector control

256th National Meeting (2018)

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