Peptidomimetics are an important class of therapeutic compounds that functions as a peptide therapeutic but with stability towards proteolysis by peptidase and predetermined structural constraints to avoid non-selective binding. In this work we used peptidomimetic compounds to bind to certain regions of ion channels that showed inhibition of selective ion channels with significantly greater potency that commercially available drugs. The peptidomimetics were de novo designed using the MD computational method, synthesized and tested experimentally in animal ion channels.<br/>We present a novel antigen delivery system utilizing self-adjuvanting dendrimer. For dendrimer construction, we applied acrylate based polymer, which is known to be easy to synthesize and have little or no toxicity. Self-assembly of these dendritic structures into nanoparticles allowed proper presentation of antigen (e. g. required α-helix conformation) to immune system and elucidated a strong immune response in mouse model.

Dendrimer peptidomimics and polymers for drug and vaccine delivery

256th National Meeting (2018)

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