Hydroxyl radical is one of the most reactive and dangerous free radical species. The imbalance of generation and elimination of hydroxyl radicals in human body causes various diseases such as cancer, tumor, aging, and neurodegenerative diseases. Thus, it is important to have the practical method to monitor and determine the concentration of hydroxyl radicals. In this research, we are developing the reusable composite sensor with high selectivity and sensitivity toward hydroxyl radicals. The sensor comprised of two layers of inorganic materials. The first layer is Prussian blue (PB) used as a selective electrochemical catalyst. PB was deposited into the glassy carbon electrode (GCE) by the electrochemical deposition method. The second layer is the composite of cerium oxide (CeO<sub>2</sub>) and graphene oxide (GO) used as the sensing element. The composite was modified on PB deposited GCE by the drop-casting method. The cyclic voltammetry (CV) and scanning electron microscopy (SEM) were used to confirm the successful modification with two layers of PB and composite materials. Cyclic voltammogram showed that this sensor could detect the presence of hydroxyl radicals with consistent data for multiple detecting times in Fenton reaction. Furthermore, the degradation of PB was investigated to study the reusable property of this sensor. We found out that the first layer of PB was degraded in Fenton reaction. Cyclic voltammogram exhibited the increasing of sensor conductivity as the indicator for the PB degradation after using in Fenton. Besides, SEM images showed the surface of PB was rougher and less organized compared to that before detecting hydroxyl radicals. However, the degradation of PB showed the slight effect on the efficiency of this sensor for hydroxyl radical detection because it gave the consistent results within three times of detection. From the preliminary results, this sensor could be considered as a new practical device for hydroxyl radical detection.

The study of cerium/graphene oxide composite modified prussian blue sensor for hydroxyl radical detection

256th National Meeting (2018)

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