Over the last 20 years, a significant amount of research has focused on polyphenol compounds in plants for their potential benefits on human health. Flavonoids represent a large class of at least 6000 phenolic compounds found in fruits, vegetables, nuts, grain seeds, cocoa, chocolate, tea, soy, red wine, herbs and beverage products. Flavonoids can function as antioxidants to prevent diseases by modulating oxidative stresses in the body. Given the hypothesized relation between diabetes and inflammation, and potential to protect the body against free radicals, it suggests that consumption of flavonoids or flavonoid-rich foods may reduce the risk of diabetes.<br/>This review summarizes the current progress in the study of alleviating insulin resistance through inflammatory signaling of natural flavonoids and their molecular mechanisms for preventing and/or treating insulin resistance and diabetes. which provides amounts of data published in recent 20 years, including main flavonoids (flavone, isoflavone, flavonol, kaempferol, bioflavone), experiment cell and animal models, compound dosage, active pathway and target and effect mechanism, in vitro and vivo.

Flavonoids alleviating insulin resistance through inflammatory signaling

256th National Meeting (2018)

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