Fluorescent gold nanoclusters conjugated with 2A3 antibody (2A3-AuNCs) were developed for assessment of cancer progression and inhibition of cancer cell proliferation. The 2A3 antibody can specifically bind onto carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) on the cancer cell surface to decrease cancer cell proliferation, metastasis and angiogenesis. In this work, the target-specific 2A3-AuNCs were applied as the fluorescent probes to target CEACAM6 overexpressed pancreatic cancer. After binding with CEACAM6, the fluorescence changes of 2A3-AuNCs were measured and calculated to simulate their kinetics for assessment of pancreatic cancer progression by time-lapse confocal fluorescence microscopy. Moreover, the fluorescence imaging and fluorescence change of 2A3-AuNCs were applied to investigate their possibility for inhibition of pancreatic cancer cell proliferation. Eventually, we hope that we will be able to develop a practical application of target-specific AuNCs as a fluorescent probe for assessment of cancer progression and inhibition of cancer cell proliferation.

Development of target-specific 2A3 antibody-conjugated gold nanoclusters for assessment of cancer progression and inhibition of cancer cell proliferation

256th National Meeting (2018)

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