The use of mechanical force to induce chemical transformations is well positioned as a sustainable technique with a vast number of potential applications. Although intuitively unlikely, it has been recently demonstrated that biocatalytic processes can take place under conditions of mechanical stress. The work presented here focuses in the use of enzymes, specifically lipases such as Candida antarctica Lipase B (CALB), to carry out the enzymatic resolution of a broad range of racemic substrates. In particular, the successful simultaneous application of mechanochemical activation and enzymatic enantiodiscrimination resulted in efficient kinetic resolution of β3-amino esters, affording β3-amino acids with high conversion and high enantiomeric purity. As shown in the present work, mechanochemistry can be used in combination with enzymatic catalysis in the enantioselective preparation of valuable products.

Simultaneous application of mechanochemical activation and enzymatic enantiodiscrimination in efficient kinetic resolution of β3-amino acids

256th National Meeting (2018)

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