<br/>Recent advances in hyperspectral stimulated Raman scattering microscopy has allowed acquisition of a Raman spectrum within a few microseconds. This capacity enables fast analysis of a large number of cells within seconds on a novel platform termed stimulated Raman cytometry. Based on this platform, we have unveiled transient signatures that define the function of cancer stem cells. Further study of the biology underlying such signatures led to a cancer stem cell specific therapy. We have further applied stimulated Raman cytometry for early determination of anti-microbial susceptibility within 30 min, which allows timely section of appropriate antibiotics for treatment of infections. Finally, we show SRS cytometry in a flow setting, which allows high-throughput chemical analysis of single cells.<br/>

Stimulated Raman cytometry: Unveiling dynamic signatures in single cells for precision diagnosis and treatment

256th National Meeting (2018)

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