The Palladium catalyzed reaction of aryl halide (iodide, bromide, chloride), and aryl pseudohalides (e.g. triflate, tosylate, mesylate) with various substrates is a general method employed for the formation of C-C, C-N, C-O bonds, which plays an important role in synthesis of fine chemicals, agricultural and pharmaceutical products, and advanced materials. The reactivity of the palladium catalyst is greatly influenced by its structural features and the number of associated ligands to the metal. Mono-ligated palladium complexes, bearing one bulky and electron-rich ligand, have been demonstrated to be highly effective catalysts/precatalysts. Among such examples are Buchwald’s biphenylpalladacycle precatalysts and Johnson-Matthey’s allylpalladium (II) complexes. Here we report a type of very simple, and highly efficient mono-ligated arylpalladacyle precatalysts (Figure below). In Suzuki reactions these precatalysts exhibit mild reaction conditions, low catalyst loadings, short reaction times, and provide high yields. Their ease to prepare, stability to air and moisture could make them desirable for applications in large-scale industrial processes.

Simple and highly effective mono-ligated arylpalladacycle complexes for Suzuki cross coupling reactions

256th National Meeting (2018)

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