With the coming big-data and systems biology era, there is exploding demand for simultaneously imaging a large number of molecules inside cells. However, the prevalent fluorescent microscopy exhibits a fundamental limit of “color ceiling”: in practice, no more than 6 targets can be simultaneously imaged. As a result of such limited multiplexity of conventional light microscopy, cell heterogeneity are less understood, many disease biomarkers are missed in the diagnosis, tumor subtypes are poorly classified, and drug screening are slowly conducted. We will present a novel optical microscopy that allow for system-wide labeling and visualization of a much greater number of molecules in living cells and tissues than is currently attainable. Our approach is to abandon fluorescence and develop new Raman microscopy instrumentation together with novel vibrtional imaging probes. This platform could have far-reaching impact in biomedicine and biotech industry.<br/>

Super-multiplex vibrational imaging for biomedicine

256th National Meeting (2018)

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