Chiral bifunctional Brønsted bases have been used to catalyze [4+2] cycloadditions between tropolones and electron-deficient dienophiles yielding functionalized dihydrohomobarrelenones. The reactions proceed in a stereoseletive manner and the chiral cycloadducts can be further modified.

Organocatalyzed asymmetric [4+2] cycloadditions: Constructing complex scaffolds by utilizing tropolones

256th National Meeting (2018)

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