Na/K-ATPase was discovered as an ion pump. We are the first to report the Na/K-ATPase has an ion-pumping independent signaling function that is important for the regulation of cardiac growth and function. Specifically, Na/K-ATPase serves as a master regulator of pathological ROS signaling. In view of well-established effects of tea on cardiac mortality, we have become interested in looking at the potential interaction between tea polyphenols and Na/K-ATPase in the heart. In this presentation, I will first discuss our in vivo studies of tea polyphenol on cardiac remodeling, and our ex vivo studies of tea polyphenol and ECG on cardiac contraction and ischemic/reperfusion injury. In the second part, I will share our recent investigation of ECG-induced signal transduction in the heart. Finally, I will discuss the potential role of Na/K-ATPase in ECG-induced signal transduction.

Receptor Na/K-ATPase, ECG and heart

256th National Meeting (2018)

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