Single-chain polymeric nanoparticles (SCPNs), formed by the controlled intramolecular crosslinking of linear polymers, have received intense interest because of their finely tuned properties. Applications of SCPNs have been reported in bioimaging, nano-assembly, and catalysis. Catalysis by SCPNs is particularly interesting because their enzyme-like structure can afford significant increases in efficiency, selectivity, and stability. This talk will focus on a copper crosslinked single-chain polymeric nanoparticle (CuSCPN) that folds by both hydrophobic interactions and coordination between amino acid side-chains and copper ions. The CuSCOPNs significantly improve the efficiency of CuAAC click reactions in aqueous media with ppm catalyst loadings. A structure-activity relationship was carried out using a fluorogenic click reaction, demonstrating the enzyme-like binding process between the polymer scaffold and substrates. Understanding the detailed mechanism of SCONP based catalyst as well as their structure-activity relationship may facilitate future designing of highly efficient polymeric catalysts with different functionalities, and expanding their potentials applications.

Highly efficient single-chain organic nanoparticle catalyst for click chemistry

256th National Meeting (2018)

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