Commercial compound databases represent rich sources of potential starting points for pharmaceutical and agrochemical product development. Routine screening of compounds acquired from these sources led to the identification of a 3-aminopyridyl urea with activity against the sap-feeding insect pest <i>Myzus persicae </i>(green peach aphid). A series of ureas based on the structure of this intial hit were synthesized and screened for insecticidal activity. While a number of these compounds also showed activity on <i>M. persicae</i>, activity on other important sap-feeding agrochemical pests was lacking. Nevertheless, this work demonstrates the viability of commercial compound acquisition as a strategy for identifying actionable agrochemical hits.

Discovery of insecticidal 3-aminopyridyl ureas

256th National Meeting (2018)

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