Recognition of chirality, and the determination of optical purity, is a skill needed in organic, biochemistry, and in the pharmaceutical industry. Traditional methods use optical rotation and/or chiral chromatography to determine chemical as well as optical purity. The employment of chiral shift reagents to determine enantiomeric excess is a method often not covered in undergraduate organic chemistry. Utilizing a benchtop NMR, a first semester NMR/Chiral Lab has been developed. We will present our initial findings and student feedback from this laboratory experience.

Use of benchtop NMR with classical resolutions to resolve over the counter analgesics; an undergraduate organic chemistry laboratory

256th National Meeting (2018)

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