A metal-free oxidative difunctionalization of <i>N</i>-allylamides and <i>N</i>-allylthioamides has been developed. This system features the use of a hypervalent iodine oxidant with electron-deficient amines to access 5-amino-oxazoline and thiazoline scaffolds under mild conditions. Notably, various electron-deficient amines were systematically evaluated and we verified the reaction profile was originated from an attached (benzene)sulfonyl group.

Novel method development for the synthesis of oxazoline and thiazoline

256th National Meeting (2018)

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