Cross-electrophile coupling, the direct cross-coupling of two different carbon electrophiles under reducing conditions, has rapidly become a useful tool in organic synthesis. Our work in the area has benefited from discussions and collaborations with industry, including the ACS Green Chemistry Institute Pharmaceutical Roundtable. The outcome of these interactions has been several breakthroughs in cross-electrophile coupling – reactions without stoichiometric metal, reactions in greener solvents, and better ligands that allow the use of heterocycles and less reactive substrates. After some background on the collaborations, the development and scope of these reactions will be discussed, including our latest results.

Better together: Improved cross-electrophile coupling reactions from industry collaboration

256th National Meeting (2018)

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