Many neurological diseases are difficult to diagnose in the early stages of disease progression where treatment would be most beneficial. For various diseases, changes in neurotransmitter concentrations indicate the onset or progression of the disease. Neurotransmitters can also be detected in biofluids, however most analytical techniques used for neurotransmitter detection often involve long sample processing and measurement times. There is a need for the development of sensors for the detection of neurotchemicals in a selective, rapid, label-free, non-invasive manner with little to no sample processing. Our group is focusing on the development of plasmonic sensors for the detection of biomarkers related to neurological disease/conditions in non-invasively collected biofluids using surface enhanced Raman spectroscopy (SERS) and through the skull using SERS combined with spatially offset Raman spectroscopy (SESORS).

<i>In vitro </i>and<i> in vivo </i>neurochemical detection for early-onset neurological disease diagnosis with Raman spectroscopy

256th National Meeting (2018)

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In vitro and in vivo neurochemical detection for early-onset neurological disease diagnosis with Raman spectroscopy