The traditional approach to quality within the agricultural industry is to perform testing post batch to ensure it has met the critical quality specifications. If the specifications are not met, then the batch would be a failure and discarded. Traditional analytical testing in a manufacturing quality control laboratory is generally very time-consuming and costly due to required manual sampling and sample preparation. What if we could reduce or eliminate failures and the time spent manually sampling and preparing samples? Process analytical technology (PAT) is a mechanism to design, analyze, and control manufacturing processes through the measurement and monitoring of process parameters preferably inline or online and thus being more time and cost efficient in testing while at the same time, enhancing consistency and minimizing failures. This presentation will discuss online or inline methods for process monitoring of Monsanto’s active ingredient processes. This will include discussion of the specialized instrumentation, successful implementation and method development that went into establishing the PAT. Methods discussed will include the use of IR, Raman spectroscopy and online gas chromatography.

On-line measurements for process monitoring, development and manufacturing of Monsanto’s crop protection products

256th National Meeting (2018)

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