Many methods suitable for multi-class, multi-residue analysis implement an extraction capable of dissolving diverse analytes and consequently, large amounts of matrix co-extractives including lipids. Traditional cleanup materials struggle to effectively and selectively remove unwanted lipids resulting in low analyte recovery, poor method reproducibility, and increased instrument maintenance.  A new family of materials, <i>Enhanced Matrix Removal – Lipid (EMR-Lipid)</i>, provides easy and selective lipid removal from fatty samples prior to LC-MS and GC-MS analysis.  Sample extracts are passed through packed SPE cartridges or 96-well plates where unbranched hydrocarbon chains (lipids) enter the sorbent and are trapped by hydrophobic interactions.  Target analytes are too bulky to enter the sorbent and remain in solution for analysis.  Data will demonstrate the high recovery, reproducibility, and lipid removal achieved using EMR-Lipid in a simplified, pass-through workflow.  This technology represents a breakthrough in lipid selective chemistries and is ideal for laboratories seeking to simplify sample preparation and improve analytical performance.  The novel lipid removal mechanism facilitates trace analysis in diverse applications including veterinary drugs, pesticides, mycotoxins, and drugs of abuse in complex, fatty samples.<br/>

Lipid selective SPE materials simplify sample preparation and improve results

256th National Meeting (2018)

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