Microbial secondary metabolites continue to inspire chemists and biologists alike with their fascinating structures and potent biological activities. Investigations into their biosynthetic pathways not only provides possible means of creating these molecules in the laboratory, but can also reveal unusual enzymatic reactions. In this talk, I will present new transformations that my group has discovered in the biosynthesis of complex natural products, with a focus on carbon-carbon bonds installed by metalloenzymes. Results from detailed analyses are pointing to new mechansitic paradigms that are likely wide-spread in biological systems. Our efforts are expanding the scope of reactions that microorganisms have at their disposal in concocting bioactive small molecules.

New metalloenzyme-catalyzed transformations in natural product biosynthesis

256th National Meeting (2018)

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