In recent years, organic synthesis has become increasingly oriented towards alternative and non-conventional methodologies, with the aim of achieving synthetic procedures that are cleaner, safer as well as more energy- and materials-efficient. Of particular interest in the development of such Green Chemistry techniques for research and manufacturing is mechanochemistry, i.e. chemical reactivity induced or sustained through mechanical force. Mechanochemical reactions have attracted the attention of a wide range of chemistry researchers, by providing not only cleaner, safer routes for room-temperature and solvent-free synthesis, but also by permitting the synthesis of previously inaccessible targets. However, the applications of mechanochemistry are hindered by difficulties of reaction scale-up, as laboratory-scale ball milling processes are not readily adaptable to manufacturing-scale planetary or attrition mills. In order to resolve this long-standing problem of mechanochemical synthesis, we now present the use of resonant acoustic mixing (RAM) as a novel mechanochemical method that permits chemical transformations on milligram, as well as multi-gram scales, without introducing major changes in equipment design. By using a selection of organic transformations, including condensation, catalytic coupling, and ring expansion processes, this presentation will illustrate the general applicability, as well as scalability, of the mechanochemical RAM methodology.

Mechanochemical synthesis based on resonant acoustic mixing

256th National Meeting (2018)

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