Chiral biaryl compounds can be challenging to access synthetically. Yet, this class of compounds includes desirable targets with utility as ligands in asymmetric catalysis, ligands for biological targets, and intermediates in natural product synthesis. Nature has evolved biocatalysts for  site- and atroposelective biaryl bond formation within natural product pathways.  Complimentary enzymes have been investigated as general biocatalysts capable of the atroposelective coupling of phenolic compounds. The scope of the reaction for various aromatic substrates has been investigated.<br/>

Biocatalytic biaryl bond formation

256th National Meeting (2018)

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