Although proteins are synthesized only in specialized cellular locations, they are destined for delivery to all corners of the cell—and beyond. A key step in this delivery process is the efficient transport, or translocation, of the newly synthesized proteins across cell membranes, which involves a delicate balance between molecular processes. Recent studies offer high-resolution glimpses into the translocation process, but many fundamental aspects of its mechanism and regulation remain poorly understood. I will present our lab’s efforts to computationally simulate the protein translocation process and to predict ways of controlling the <i>in vivo</i> targeting and delivery of proteins. This work employs methods that span across atomistic simulation, coarse-grained methods, machine learning techniques, and experimental collaborations.

Understanding and improving membrane protein expression in cells

256th National Meeting (2018)

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