Glycosidases are enzymes responsible for hydrolytic cleavage of glycosidic bonds in metabolic pathways in microorganisms, plants and animals. Thus, their function or dysfunction is related to diseases such as diabetes and lysosomal storage disorders. In addition, glycosidases are potential targets for treatment of inflammations, viral or bacterial infections, and the treatment of tuberculosis, HIV and cancer. Recently we demonstrated the effect of 4-hydroxy-5-alkoxy-1,2-cyclohexanedicarboxylic acid derivatives on activity of β-D-glucosidases and β-D-galactosidases isolated from fungi Aspergillus and Penicillium sp. With the growing use of the triazole substituent in pharmaceuticals, and the emergence of new pyrrole, imidazole, and tetrazole-based glycosidase inhibitors, new triazolyl-1,2-cyclohexanedicarboxylic acids and triazolyl-cyclohexanol derivatives are of interest and were synthesized for the first time through “click reaction” of the corresponding azides and alkynes, and tested for their regulatory activity.

Exploration of triazolyl-1,2-cyclohexane-hydroxy-dicarboxylic acids and triazolyl-cyclohexanols as potential regulators for glycosidases

256th National Meeting (2018)

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