Our recent findings show that pure, biocompatible platinum nanoparticles (Pt NPs) are able to counteract molecular dysfunctions that cause accumulation of intracellular reactive oxygen species (ROS). After performing a systematic characterization of Pt NPs as biocompatible and anti-oxidant materials, we demonstrated, for the first time, that Pt nanozymes are capable to restore physiological ROS homeostasis in a real experimental model of a human cerebrovascular disease, namely Cerebral Cavernous Malformation (CCM). CCM is characterized by an increased level of intracellular ROS, and we found that Pt nanozymes can completely recover the cellular phenotype, similar to that of wild type cells. This is possible because of the strong and broad anti-oxidant nanozyme activity of Pt NPs, which are simultaneously endowed with strong catalase-, peroxidase-, and superoxide dismutase-like activities, with superior performance than natural enzymes and higher adaptability/resistance to changes in environmental conditions. These findings are important and of broad interest, and open up novel perspectives in nanomedicine for the development of multifunctional active nanocarriers integrating the function of high-performance antioxidant drugs, with strong potential for therapies of complex oxidative stress-related diseases. We will also present our latest data on the importance of platinum nanoparticles shape (octahedral vs spherical) in the development of nano-carrier with selective enzymatic activity, uptake and drug-delivery properties.

Highly engineered platinum nanoparticles as multifunctional active nanocarriers integrating the function of high-performance antioxidant drugs

256th National Meeting (2018)

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