Research in our laboratory focuses on the interactions of transition metal complexes to functionally relevant messenger and ribosomal RNAs.  The search for alternative metallopharmaceuticals and thus the design of metal complexes having more than one metal center has risen considerably, motivated by incorporating favorable properties of each metal center in a single compound.  We have compared the efficacy of multinuclear metal complexes with existing pharmaceutical agents like Cisplatin in their binding to RNA and inhibition of vital cellular processes. Reverse transcription studies show that IT127, a complex containing ruthenium and platinum, binds to Sarcin Ricin Loop of 28S ribosomal RNA at purine rich and solvent accessible regions. Current results with a translation model system show that IT127, upon binding to mRNA, exerts an inhibitory effect on protein synthesis, which appears to be synergistic in nature, due to the presence of two metal centers.

Regulation of RNA using novel transition metal complexes

256th National Meeting (2018)

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