Organization of functional nanomaterial is important in both scientific and technological fileds due to their applications in biomedical, electronical and optical materials. DNA is well-known for its specific Watson-Crick base pairing, which makes it an ideal tool for nanofabrication platform. Here, we describe a general framework for constructing one- and two-dimensional DNA crystals with prescribed spacing, which is controlled by bridge DNA with its axis perpendicular to that of crystals. DNA crystals with micrometer size are constructed by single-stranded DNA components and packed in square lattice. Bridge DNA, double helices with variable lengths ranging from 11 to 53 base pairs, are incorporated in crystals between each 18 helices bundle. They can be designed to separate the close-packed DNA helices and provide nanometer-precision spacing for functional moiety patterning.

Self-assembly of DNA crystals with tunable spacing

256th National Meeting (2018)

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