The EPA Office of Pesticide Programs has formally committed to advancing the use and acceptance of robust twenty-first century toxicity testing approaches that are more efficient, less expensive, and use fewer animals than traditional methods (http://bit.ly/2nyJx7k). These approaches will enhance the quality of EPA’s risk assessments and risk management decisions and better protect human health and the environment. A near-term goal was established to replace the “6-pack” of animal tests (acute oral, dermal, and inhalation systemic toxicity, skin irritation, skin sensitization, and eye irritation) for agrochemical formulations. Many companies and non-governmental organizations share EPA’s goal to replace animal tests for agrochemical products and thus multi-stakeholder collaborations have formed to work collaboratively towards this mutual goal. This presentation will discuss ongoing collaborative projects and progress made to replace the “6-pack” for testing agrochemical formulations, including gathering existing data to use for model development and validation as well as the use of waivers, <i>in silico</i> and <i>in vitro</i> models, and the GHS additivity equation.

Multi-stakeholder collaborations to advance non-animal approaches for testing agrochemical formulations

256th National Meeting (2018)

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