DNA nanopaticle has attracted attention as a therapeutic oligo nucleotides delivery tool. There is a DNA nanostructure that can precisely control particle size and shape by using DNA nanotechnology. Acording recent studies, tetrahedral DNA nanoparticle can uptaking to immunocyte without being degraded by nuclease.<br/>This reserch shows developing new concept of DNA nanoparticle with self-assemblly of pH-triggered nucleic acid ion complex, using morphorino nucleotide(PMO) of chemically modified oligonucleotide(ODN). The conjugated DNA-(polyethylene grycol(PEG))PEG and PMO-PEG formed double strand sequence at pH 7.4. At decreasing pH led to protonation of the PMO-PEG, resulting in aggregation of the ion complex. This aggregation was controlled by using sequence specific hydrogen bounding, charge intaraction and conjugate-direction and molecuraweight of PEG.

Programmable DNA nanoparticle: Self-assemblly of pH-triggered nucleic acid ion complex

256th National Meeting (2018)

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