Organic nitrate esters have been of interest lately as potential Nitric Oxide (NO) donors.. A series of nitrate ester analogues of SCP-1 were prepared by acylating SCP-1 with chloroalkanoyl chlorides followed by nitration using AgNO3 to give the corresponding nitrate ester. The chloroesters and nitrate esters were obtained in good yields. 1H NMR and 13C NMR were used to characterize the compounds. X–Ray crystallographic analysis unequivocall yconfirmed the structures of the chloroester and the nitrate ester. The preliminary biological evaluation of the hepatotoxicity has shown these compounds to be well tolerated by human hepatocytes The synthesis of nitrate ester derivatives of the analgesic SCP-1 and preliminary biological activity will be presented.

Design, synthesis and biological evaluation of nitrate ester analogs of SCP-1

256th National Meeting (2018)

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