The ability for non-invasive point-of-care diagnostics of multiple cancer biomarkers in complex aqueous media with high sensitivity and selectivity is crucial for the early stage detection of cancers, which could dramatically increase the survival rate.  One of the key challenges is the creation of nanoprobes with both bio-compatibility and bio-intervention capabilities while achieving effective detection of biomolecular activities. This report discusses recent results of an investigation of a multifunctional nanoprobe for simultaneous detection of selected lung cancer biomarkers (e.g., carcinoembryonic antigen (CEA), Neuron-Specific Enolase (NSE)) using surface enhanced Raman scattering technique. The nanoprobe features a multi-core/single-shell structure synthesized by a combination of hydrothermal and seed growth methods.  The sensitivity, selectivity and detection limit will be discussed, along with their implications for the design of nanoprobes for advancing early cancer detection and diagnostics.<br/>

Functionalized magnetic-plasmonic nanoprobes for surface enhanced Raman spectroscopic detection of cancer biomarkers

256th National Meeting (2018)

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