Environmental Exposure Assessment depends on environmental fate properties of an agrochemical, including sorption and degradation behaviors.  Therefore, kinetics evaluation of environmental fate studies is very critical to exposure and risk assessment. The PESTDF tool is used to implement the NAFTA guidance to characterize degradation rates in environmental media for regulatory purposes in the US and Canada.  While the NAFTA guidance provides a general procedure for kinetic analysis, it does not consider specific study conditions (such as microbial activity) which can significantly impact degradation behavior.  Therefore the resulting half-life may not reflect real degradation rates, especially for studies conducted under older guidelines.  There are also examples where the derived half-lives following the guidance are not supported by the studies because of conservative assumptions incorporated in the kinetic analysis. Case studies will be presented to demonstrate that study data must be evaluated for its suitability in the kinetic analysis.<br/>

Kinetic evaluation of environmental fate studies

256th National Meeting (2018)

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