Peroxidases have been extensively used in biosensing for decades because of their simplicity and reliability in producing colorimetric detection signal. Nevertheless, the detection sensitivities of peroxidases-based biosensing techniques are inherently limited by the catalytic efficiency of peroxidases. In this talk, I will introduce our recent research on development of metal nanocrystals as peroxidases mimics for biosensing applications. With careful control over the shape, size, and composition of nanocrystals, we were able to engineer a series of peroxidases mimics with substantially enhanced catalytic efficiencies relative to their natural counterparts. Experimental design, chemical synthesis, structural/compositional characterizations at the atomic level with high-performance electron microscope, and mechanistic understanding with computational modeling for the peroxidase mimics will be illustrated. Applications of these peroxidase mimics in biosensing will be highlighted.

Metal nanocrystals as peroxidase mimics for biosensing applications

256th National Meeting (2018)

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