A conjugated Dendron with a photo cleavable linkage to glycine, Glycine caged bis-1,2 -(4-acetylphenylethynyl)-4,5- dimethoxybenzene, is synthesized as a model for photochemical drug delivery. The Dendron is successfully synthesized in convergent manner and has tested for photoreactivity under various conditions. Photo reaction is observed in aqeous acetonitrile by NMR and UV- visible spectrometer. The products are isolated and being characterized. The detailed mechanism including molecular modeling study will be also presented.

Photochemical release of glycine from excited state dendrimer: An example of novel drug delivery

256th National Meeting (2018)

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