The number of patients who live with dementia is increasing and Alzheimer’s disease (AD) is the most common type of dementia. β-amyloid (Aβ) accumulation and deposition in brain tissue are one of the most important hallmarks of disease. Therefore, Aβ is an attractive target for imaging Alzheimer’s disease. However, designing a nanoprobe with the ability to pass through the blood brain barrier (BBB) and reaching Aβ plaques is a significant challenge. In this work, development and synthesis of a glyconanoparticle for in vivo imaging of Aβ plaques will be presented. Briefly, characterization of this nanoprobe, its binding with Aβ fibrils and in vitro ability to pass through BBB will be discussed. Then, application of this glyconanoparticle for imaging Aβ plaques in an animal model of AD and related histological studies will be presented.<br/>

β-amyloid detection in an animal model of Alzheimer’s disease using glyconanoparticle

256th National Meeting (2018)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.