During the last several decades, controlled drug delivery technology has advanced significantly leading to the development of various clinical formulations improving patient compliance and convenience. Varieties of organic and inorganic nanomaterials have been extensively explored as a delivery system either in the form of drug carriers or imaging modalities.  Of this system, one of the first FDA-approved nanomedicine is DOXIL<sup>®</sup>, a PEGylated liposomal doxorubicin. This class of conventional nanomedicine relies on passive-drug targeting taking advantage of leaky tumor vasculature, called as Enhanced Permeability and Retention (EPR) effect. However, delivering the drug to the cancer cell in the tumor with heterogeneous microenvironment is highly challenging. To tackles these problems, attention has shifted towards the design of next-generation delivery vehicles with enhanced targeting functionalities for active delivery. In this talk, two different strategies to engineer active targeted drug delivery system will be discussed. First, a class of bone microenvironment targeted polymeric nanomedicine will be presented with various chemical approaches from polymer synthesis and lipid conjugation using Alendronic acid, a bone targeting ligand, as a building block of the design. Secondly, with the inspiration from the properties of the natural killer cell, state of the art cell membrane coated polymeric nanosystem for precise drug delivery will be implemented to achieve a high level of accumulation within the diseased tissue, improved circulation half-life, and minimal sequestration by the organs of the reticuloendothelial system. The talk will be concluded with the properties and finding of these engineered nanoconstructs including superior contrast enhancement properties for imaging, pharmacokinetics, and therapy.<br/>

Biologically inspired design consideration for polymeric anticancer nanomedicine

256th National Meeting (2018)

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