The Hierarchical Editing Language for Macromolecules (HELM) is an open biomolecular representation standard that provides a means to represent multiple types of complex macromolecules (e.g. nucleotides, proteins, antibodies and antibody-drug conjugates) including those that contain non-natural elements.<br/>Oligonucleotides are seeing more and more use in research and as a therapeutic drug. Their variability can be increased heavily by using non-natural elements. However, the biological effect is biased towards elements with a similarity to a natural analog. A new algorithm that allows users to establish a similarity measure between arbitrarily complex biomolecules was recently developed by quattro research. Based on the calculation of fingerprints from HELM notations, we analyzed the similarity of oligonucleotides in comparison to their chemical similarity. The HELM similarity library can analyze complex polymers and nucleotides with non-natural elements. This is an outstanding feature in comparison to sequence-based tools.<br/>

Similarity analysis of oligonucleotides based on HELM notation

256th National Meeting (2018)

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