Antimicrobial coatings have emerged as a solution to prevent bacterial contamination, particularly in the case food packaging materials, water treatment membranes and medical devices and implants. Infections caused by bacterial contamination of medical devices such as stainless-steel IV poles and implants, is a serious healthcare problem. Designing a biocompatible coating with antibacterial activity is crucial for limiting contamination, especially on medical devices and implants to prevent the spread of infections in patients. Protein-based materials have come forth as potential candidates for designing biocompatible and sustainable biomaterials. Translating protein precursor properties into protein films is essential for various biological applications such as tissue engineering and controlled drug release.  Herein, we demonstrate the use of charged protein films that can be used to load and control release antibiotics via electrostatic interactions. These drug-loadable protein films are prepared by an additive-free strategy, utilizing a fluorous media to thermally treat and stabilize the coating. They can be used to design conformal coatings on complex three-dimensional substrates. Moreover, they are stable in physiological conditions, sustainable and biodegradable thus making them well suited for medical implants.<br/>

Fabrication of drug-eluting coatings by harnessing electrostatic interactions with native protein films

256th National Meeting (2018)

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