Engineered materials in the nanoscale are revolutionizing all areas of life science, thanks to their novel physicochemical properties. There are many different aspects that need to be considered when designing nanomaterials for in vivo targeting. The dispersion size and stability, possible non – specific interactions and targeting capabilities all need to be well understood and controlled. However, it becomes crucial to know how an engineered nanomaterial acts when inside a biological system. The interaction of nanoparticles with the biological environment results in the formation of a biomolecular corona, which substantially modifies the nanoparticle surface properties, and ultimately mediates the interactions of nanoparticles with cells and organisms. It has been shown that the material, size and shape of a nanoparticle all affect the composition of the formed corona. The composition and architecture of the biomolecules on their surface in turn affect the bio-interactions and thus in vivo nanomaterial destination. By using the physicochemical properties of inorganic nanoparticles, such as plasmonic heating, allow us to control the corona composition, the long-lived protein coating, as well as the exposure of certain protein domains on the nanoparticle surface that could lead to different nanomaterial destination and trigger specific cellular responses.

Controlling biomolecular corona by plasmonic metal nanoparticles

256th National Meeting (2018)

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