Investigations on the enzymatic oxygenation of DHA led to the discovery and study of several types of resolvins, protectins, and maresins, which promote the resolution of inflammation, and are known as specialized pro-resolving mediators (SPM).  More recently, these efforts led to the identification of several new types of DHA-derived sulfidoconjugate derivatives, including the protectin conjugates in tissue regeneration (PCTR), and similar sulfidoconjugates derived from maresin precursors (MCTR), or resolvin precursors (RCTR).  We have previously completed the stereocontrolled total synthesis of MCTRs and PCTRs, that confirmed their structure and stereochemistry, and their postulated biosynthesis, and also enabled the study on their novel biological actions.  Our synthetic strategy was based on the stereocontrolled total synthesis of the epoxide precursors of MCTRs and PCTRs, followed by opening the epoxide by glutathione and related cysteine components.  Herein, we detailed our recent efforts aimed at the stereocontrolled total synthesis of novel resolvin-related sulfidoconjugates.<br/>

Stereocontrolled total synthesis of novel resolvin-related sulfidoconjugates

256th National Meeting (2018)

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