Functionalized nanoparticles have been reported to have enhanced biological response compared with non-functionalized nanoparticles, but the response can vary significantly depending on the nanoparticle composition and the molecular structure of the surface molecular layers. Diamond nanoparticle provides an ultra-stable platform for investigating how surface properties influence nanoparticle behavior and therefore is an ideal material for mechanistic studies of nanoparticle aggregation and toxicity. However, to come to fruition it is necessary to develop more scalable, robust, benign, and selective method of functionalizing diamond nanoparticle. In our previous work, we have used photochemical grafting methods to modified diamond nanomaterials; but these methods are not readily applied to many applications due to the inefficient nature of the photochemical grafting mechanism. Recently, we have developed a novel surface functionalization method using radical chemistry to attach alkene terminal ligands to diamond nanoparticle surface. In this talk we will explore attaching various alkene terminal ligands (both hydrophobic and hydrophilic) on diamond nanoparticle surface, as well as other carbon-based materials. We will demonstrate details on how these ligands bind to the nanoparticle surfaces, and provide characterization of the corresponding surface/ligand structures after functionalization using X-ray photoelectron spectroscopy and high-resolution (liquid phase) NMR.

Surface modification of carbon-based material with terminal alkene ligands using radical coupling reactions

256th National Meeting (2018)

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