A low-cost and convenient portable electrochemical sensing device aiming to overcome the obstacles of power supply requirement and chip usefulness in practice is introduced, featuring bipolar electrode system, LED read-out, laminated paper-based devices, and low-voltage button cells. The electric circuits of this practical device are constructed on laminating films with copper and conductive carbon tapes, and the reservoirs facilitating chemical reactions are made with chromatography paper. The device is sensitive to electrochemical responses, as validated by the demonstrative hydrogen peroxide and enzyme-assisted glucose detection. The business-card-size chip offers sensitive analyte detection by naked eyes, and the results can be further analyzed via image processing softwares. For both laboratory samples and human serum samples, detection limit as low as 1.79 μM and a dynamic range from 10 μM to 10 mM are obtained. Most importantly, this practical point-of-care sensing chip design entails the properties of facile fabrication, simple usage, high robustness, low power consumption, and accurate sensing for a useful and portable analytical device.

Low-voltage driven portable paper bipolar electrode-supported electrochemical sensing device

256th National Meeting (2018)

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