Research in the Barrios lab focuses on developing chemical tools that can be applied to further our understanding of important biological processes. Specifically, we have developed several novel approaches to monitoring intracellular tyrosine phosphatase activity with the aim of elucidating the roles of the protein tyrosine phosphatase (PTP) family of enzymes in cellular signaling pathways. With support from the Teva Scholars program, we have been working to develop a unified approach to PTP-selective substrate and inhibitor design and providing the toolkit necessary to elucidate the biological roles of PTPs in health and disease.<br/>

Chemical probes put tyrosine phosphatase activity in the spotlight

256th National Meeting (2018)

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