Drug Discovery Initiative (DDI) of the University of Tokyo was launched to promote academic drug discovery. DDI is maintaining the largest public chemical library in Japan, which consists of about 280,000 compounds including non-commercial unique samples from universities and deposited samples from pharmaceutical companies. The chemical samples are provided to any researchers in Japan who can confidentially disclose their themes and report the assay results to DDI. The general samples themselves are free of charge, but payment for microplates and shipping is needed. DDI does not claim any right to them without our intellectual collaboration. Short training courses on chemical screening are held several times a year. The researchers may also access HTS facilities in DDI. DDI has provided more than 22 million samples to more than 500 users so far.<br/>The samples of the chemical library have been chosen mainly based on druggability and structural diversity, and added every year since 2007. Druggable unique compounds synthesized in some universities were accepted. It is difficult for many academic researchers to carry out random screening of more than 10,000 samples. In such cases, DDI can provide "core library," which is a diverse 9,600-sample set. In addition, "advanced core library" has been recently prepared in order to encourage larger-scale assays, which is another diverse 22,400-sample set. DDI has been making improvements of the chemical library such as exclusion of promiscuous hitters based on reported data, while taking into consideration the users' circumstances.

Suitable chemical library for academic researchers in Japan

256th National Meeting (2018)

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