Degradation of three lipid regulators, i.e., gemfibrozil, bezafibrate and clofibric acid, by UV/chlorine was systematically investigated. Reactive chlorine species (RCS) especially chlorine oxide radical (ClO*) played an important role in the degradation of gemfibrozil and bezafibrate whereas UV photolysis and the hydroxyl radical (HO*) mainly contributed to the degradation of clofibric acid. The first-order rate constants (k′) for the degradation of gemfibrozil and bezafibrate increased linearly with increasing chlorine dosage, primarily due to the linear increase in the ClO* concentration. The k′ values for gemfibrozil, bezafibrate, and clofibric acid degradation decreased with increasing pH from 5.0 to 8.4; however, the contribution of the reactive chlorine species (RCS) increased. Degradation of gemfibrozil and bezafibrate was enhanced in the presence of Br-, whereas it was inhibited in the presence of natural organic matter (NOM). The presence of ammonia at a chlorine: ammonia molar ratio of 1:1 resulted in decreases in the k′ values for gemfibrozil and bezafibrate, but led to an increase in that for clofibric acid. Degradation of gemfibrozil by ClO* was initiated by hydroxylation and chlorine substitution on the benzene ring. Then, subsequent hydroxylation, bond cleavage and chlorination reactions led to the formation of more stable products. Three chlorinated intermediates were identified during ClO* oxidation process. The acute toxicity of gemfibrozil to Vibrio fischeri increased significantly when subjected to direct UV photolysis, whereas it decreased when oxidized by ClO*.

Transformation pathway of lipid regulator by ClO* and the toxicity changes

256th National Meeting (2018)

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